OLETE & LETO References

Mice	HR−１
	HRM-2
	NSY-A^y

Rats	ZFDM
	OLETF & LETO

	References

HR-1	HRM-2	NSY-A^y
ZFDM	OLETF & LETO

▶ OLETF & LETO

University of Missouri
2015	Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running.
2015	Chronic NOS inhibition accelerates NAFLD progression in an obese rat model.
2015	Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training.
2014	Identification of genes whose expression is altered by obesity throughout the arterial tree.
2014	Reduced hepatic eNOS phosphorylation is associated with NAFLD and type 2 diabetes progression and is prevented by daily exercise in hyperphagic OLETF rats.
2014	Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin resistant OLETF rats.
2014	Transcriptome-Wide RNA Sequencing Analysis of Rat Skeletal Muscle Feed Arteries. Part II: Impact of Exercise Training in Obesity.
2013	Combining Metformin and Aerobic Exercise Training in the Treatment of Type 2 Diabetes and NAFLD in OLETF Rats.
2013	Differential Vasomotor Effects of Insulin on Gastrocnemius and Soleus Feed Arteries in the OLETF Rat Model: Role of Endothelin-1.
2013	Influence of regular physical activity and caloric restriction on β-adrenergic and natriuretic peptide receptor expression in retroperitoneal adipose tissue of OLETF rats.
2013	Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats.
2013	Hepatic steatosis development with four weeks of physical inactivity in previously active, hyperphagic OLETF rats.
2012	Sterculic oil, a natural inhibitor of SCD1, improves the metabolic state of obese OLETF rats.
2012	Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats.
2012	Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat.
2012	Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.
2012	Exercise and Omega-3 Polyunsaturated Fatty Acid Supplementation for the Treatment of Hepatic Steatosis in Hyperphagic OLETF Rats.
2011	Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model.
2010	Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats.
2010	Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model.
2010	Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat.
2010	Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats.
2009	Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats.
2008	Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
2008	Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats.
2008	Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat.

Kinki University
2015	Changes in plasma glucose in Otsuka Long-Evans Tokushima Fatty rats after oral administration of maple syrup.
2015	Effect of high glucose levels on amyloid β production in retinas of spontaneous diabetes mellitus Otsuka Long-Evans Tokushima fatty rats.
2015	Enhanced Production of Nitric Oxide Leads to ATP Collapse in the Retinas of Otsuka Long-Evans Tokushima Fatty Rats, a Model of Human Diabetes.
2013	Therapeutic effects of sericin on diabetic keratopathy in Otsuka Long-Evans Tokushima Fatty rats.
2013	Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka long-evans Tokushima Fatty rats by oral administration of sucrose or maple syrup.
2013	Changes in interleukin 18 in the retinas of Otsuka long-evans Tokushima fatty rats, a model of human type 2 diabetes.
2013	Effect of magnesium ion supplementation on obesity and diabetes mellitus in Otsuka Long-Evans Tokushima Fatty (OLETF) rats under excessive food intake.
2011	Involvement of interleukin 18 in lens opacification of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes.
2010	Kinetic analysis of the rate of corneal wound healing in Otsuka long-evans Tokushima Fatty rats, a model of type 2 diabetes mellitus.
2009	Enhancing effects of sericin on corneal wound healing in Otsuka Long-Evans Tokushima fatty rats as a model of human type 2 diabetes.
2009	Disulfiram reduces elevated blood glucose levels in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes.
2007	Adrenocortical insufficiency in Otsuka Long-Evans Tokushima Fatty rats, a type 2 diabetes mellitus model.
2006	Effects of running exercise on fibre-type distribution of soleus and plantaris muscles in diabetic Otsuka Long-Evans Tokushima fatty rats.
2006	Physiological characteristics of diabetic neuropathy in sucrose-fed Otsuka Long-Evans Tokushima fatty rats.
2005	Gonadal hormones and gonadal function in type 2 diabetes model OLETF (Otsuka Long Evans Tokushima Fatty) rats.
2004	Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.
2003	The effect of leptin, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) production on insulin resistance in Otsuka Long-Evans fatty rats.
2003	Hematological alterations in the Otsuka Long-Evans Tokushima fatty (OLETF) rats--a model of type 2 diabetes mellitus.
2002	Response of mesangial cells to low-density lipoprotein and angiotensin II in diabetic (OLETF) rats.

Hoshi University
2014	Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease.
2012	Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.
2012	Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.
2012	Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ET(A)-receptor expression.
2010	Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats.
2009	Chronic treatment with losartan (angiotensin II type 1 receptor antagonist) normalizes enhanced acetylcholine-induced coronary vasoconstriction in isolated perfused hearts of type 2 diabetic OLETF rats.
2009	Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model.
2009	Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes.
2009	Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats are improved by chronic treatment with thromboxane A2 synthase inhibitor.
2008	Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats.
2008	Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes.
2007	Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes.
2007	Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
2006	Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta.
2006	Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd.
2005	Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.
2004	A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.
2002	Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.
2001	Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.
2001	Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene.
2001	Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.
2000	Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.
2000	Atypical hyperplasia of choledocho-pancreatic duct epithelium in an Otsuka Long Evans Tokushima Fatty strain of rats.
1999	Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.
1999	Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.
1998	Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.

Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
2002	Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor.
2000	Decrease in triglyceride accumulation in tissues by restricted diet and improvement of diabetes in Otsuka Long-Evans Tokushima fatty rats, a non-insulin-dependent diabetes model.
1999	Examination of the pathogenesis of diabetic nephropathy in OLETF rats.
1997	Impaired beta-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM.
1997	Improving effect of carteolol on bodyweight and carbohydrate and lipid metabolic responses in the OLETF rat.
1996	Relationships between diet control and the development of spontaneous type II diabetes and diabetic nephropathy in OLETF rats.
1996	A diabetogenic gene, ODB2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB1.
1995	A diabetogenic gene (ODB-1) assigned to the X-chromosome in OLETF rats.
1994	OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain.
1992	Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain.

Hanyang University
2013	G-CSF Prevents Progression of Diabetic Nephropathy in Rat.
2013	Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat.
2013	Therapeutic effects of granulocyte-colony stimulating factor on non-alcoholic hepatic steatosis in the rat.
2012	Amelioration of diabetic neuropathy by TAT-mediated enhanced delivery of metallothionein and SOD.
2011	Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
2011	The combination of metallothionein and superoxide dismutase protects pancreatic β cells from oxidative damage.
2011	Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats.
2011	Tat-enhanced delivery of metallothionein can partially prevent the development of diabetes.

Nagoya City University
2014	Assessment of Androgen Replacement Therapy for Erectile Function in Rats with Type 2 Diabetes Mellitus by Examining Nitric Oxide-Related and Inflammatory Factors.
2009	Acupuncture modulates mechanical responses of smooth muscle produced by transmural nerve stimulation in gastric antrum of genetically hyperglycemic rats.
2009	Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin.
2002	Enhanced expression of adhesion molecules of the retinal vascular endothelium in spontaneous diabetic rats. kinase-3beta-mediated suppression of mitochondrial permeability transition.
2000	In vivo evaluation of leukocyte dynamics in the retinal and choroidal circulation
1998	Electrical properties of colonic smooth muscle in spontaneously non-insulin-dependent diabetic rats.
1998	Alteration of the properties of gastric smooth muscle in the genetically hyperglycemic OLETF rat.

Sapporo Medical University
2015	Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
2014	Type 2 diabetes induces subendocardium-predominant reduction in transient outward potassium current with downregulation of Kv4.2 and KChIP2.
2012	Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts.
2012	Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.
2010	Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.
2009	Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition.

Osaka City University
2013	S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism.
2011	Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.
2002	Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats.
1997	Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
1997	Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats.

Soonchunhyang University
2014	Diesel Exhaust Particle-Induced Airway Responses are Augmented in Obese Rats.
2013	Impaired Survival of Autologous Fat Grafts by Diabetes Mellitus in an Animal Model: A Pilot Study.
2013	Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62.
2012	The Effect of Platelet-rich Plasma on Wounds of OLETF Rats Using Expression of Matrix Metalloproteinase-2 and -9 mRNA.
2011	Increased expression of three-repeat isoforms of tau contributes to tau pathology in a rat model of chronic type 2 diabetes.

Tohoku University
2012	Administration of biotin prevents the development of insulin resistance in the skeletal muscles of Otsuka Long-Evans Tokushima Fatty rats.
2002	Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
1998	Effects of dietary biotin on enhanced sucrose intake and enhanced gustatory nerve responses to sucrose seen in diabetic OLETF rat.
1996	A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus.

University of Georgia
2014	Transcriptome-Wide RNA Sequencing Analysis of Rat Skeletal Muscle Feed Arteries. Part I: Impact of Obesity.
2014	Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin-1.
2013	Influence of regular physical activity and caloric restriction on β-adrenergic and natriuretic peptide receptor expression in retroperitoneal adipose tissue of OLETF rats.

The Jikei University School of Medicine
2014	Effects of prepubertal-onset exercise on body weight changes up to middle age in rats.
2007	The insulin sensitizer pioglitazone improves the deterioration of ischemic preconditioning in type 2 diabetes mellitus rats.
2007	Exacerbation of acidosis during ischemia and reperfusion arrhythmia in hearts from type 2 Diabetic Otsuka Long-Evans Tokushima Fatty rats.

The University of Shizuoka
2013	Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats.
2011	Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes.
2009	The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats.

Shizuoka Eiwa Gakuin University
2008	Pnlip encoding pancreatic lipase is a possible candidate for intramuscular fat accumulation QTL in OLETF rat.
2005	Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat.
2003	Capn10, a candidate gene responsible for type 2 diabetes mellitus in the OLETF rat.

Chonnam National University
2014	Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
2013	COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model.

▶ OLETF & LETO

University of Missouri

Kinki University

Hoshi University

Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd.

Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

Hanyang University

Nagoya City University

Sapporo Medical University

Osaka City University

Soonchunhyang University

Tohoku University

University of Georgia

The Jikei University School of Medicine

The University of Shizuoka

Shizuoka Eiwa Gakuin University

Chonnam National University