C3H/He Hos × Hos:HR-1
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Proper name |
Hos:HRM-2 |
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Description |
Homozygous mutants (Hrhr/Hrhr) show normal development of the first hair coat (first hair cycle). Starting at 2 weeks of age, they lose their hair coat rapidly and completely due to an abnormal second hair cycle [1, 2]. At weaning (~3 weeks of age), they are completely hairless [3]. |
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Appearance |
pigmented, without hair, unaffected |
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Genotype |
hrhr/hrhr |
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Reseach |
ultraviolet radiation induced melanogenesis |
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Development |
We crossed a HR-1/Hos male to a C3H/HeHos female. A male mouse and two female mice were born in 2007. We named these mice Hos:HRM-2. |
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Attention |
Breeding is prohibited. |
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References |
[1] Brooke, H.C. 1926. Hairless mice. J. Hered. 17, 173–174.
[2] Sundberg, J. P. & King, L. E. Morphology of hair in normal and mutant laboratory mice. Eur. J. Dermatol. 11, 357–61
[3] Suzuki, O., Koura, M., Noguchi, Y., Uchio-Yamada, K. & Matsuda, J. Zygosity determination in hairless mice by PCR based on Hr(hr) gene analysis. Exp. Anim. 62, 267–73 (2013). |
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HR−１