Hos:HR-1 References

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Mice	HR−１
	HRM-2
	NSY-A^y

Rats	ZFDM
	OLETF & LETO

	References

HR-1	HRM-2	NSY-A^y
ZFDM	OLETF & LETO

▶ HR-1

Kyoto Pharmaceutical University
2018	Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms in special diet-fed hairless mice, partly by restoring covalently bound ceramides in the stratum corneum.
2017	Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice.
2016	Hypomorphic mutation in the hairless gene accelerates pruritic atopic skin caused by feeding a special diet to mice.
2015	Dietary deficiencies of unsaturated fatty acids and starch cause atopic dermatitis-like pruritus in hairless mice.
2013	Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice.
2011	Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin
2009	Ethanol aggravates itch-related scratching in hairless mice developing atopic dermatitis.
2007	Development of numerous nerve fibers in the epidermis of hairless mice with atopic dermatitis-like pruritic skin inflammation.
2006	Involvement of skin barrier dysfunction in itch-related scratching in special diet-fed hairless mice.
2005	Atopic dermatitis-like pruritic skin inflammation caused by feeding a special diet to HR-1 hairless mice.

Ehime University
2012	Effects of ginsenoside Rb₁ on skin changes.
2011	Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice.
2011	Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice.
2009	Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice.
2009	Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice.

Seoul National University
2011	Docosahexaenoic Acid Inhibits UVB-Induced Activation of NF-κB and Expression of COX-2 and NOX-4 in HR-1 Hairless Mouse Skin by Blocking MSK1 Signaling.
2011	Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.
2010	Prevention of UV-induced skin damages by 11,14,17-eicosatrienoic acid in hairless mice in vivo.
2008	Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin--AP-1 and C/EBP as potential upstream targets.
2007	cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt.

The University of Tokyo
2013	Transdermal delivery of adriamycin to transplanted ehrlich ascites tumor in mice.
2013	Effects of oral administration of glucosylceramide on gene expression changes in hairless mouse skin: comparison of whole skin, epidermis, and dermis.
2010	Increased oxygen tension attenuates acute ultraviolet-B-induced skin angiogenesis and wrinkle formation.
2008	A report of the new allele of the mouse hairless gene (Hos:HR-1)

Hoshi University
2014	Comparative study of novel ultradeformable liposomes: menthosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam.
2013	Effect of terpenes on the skin permeation of lomerizine dihydrochloride.
2012	Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis.
2012	Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization.

Nihon University
2014	Arsine toxicity is induced by inhalation but not by percutaneous exposure in hairless mice.
2000	The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice.

Hamamatsu University School of Medicine
2013	Oral Intake of Beet Extract Provides Protection Against Skin Barrier Impairment in Hairless Mice.
2012	Oral Intake of Beet Extract Provides Protection Against Skin Barrier Impairment in Hairless Mice.

Konkuk University
2013	PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.
2012	Ligand-activated PPARδ inhibits ultraviolet B-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.

Chiba University
2013	Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis.
2011	Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model.

Osaka City University
2013	Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice.
2008	Latent Essential Fatty Acid Deficiency in a Special Diet Deteriorates Skin Barrier (Osaka City University Repository)

Kyoto University
2012	Dietary sphingolipids improve skin barrier functions via the upregulation of ceramide synthases in the epidermis.
1994	Formation of 8-hydroxy-2'-deoxyguanosine in epidermis of hairless mice exposed to near-UV.

Tohoku University
2010	Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice.
2010	Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling.

Santen Pharmaceutical Co., Ltd.
2016	Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content.

Hiroshima University
2016	Oral administration of β-carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice.

Meiji Co., Ltd.
2015	A novel mechanism for improvement of dry skin by dietary milk phospholipids: Effect on epidermal covalently bound ceramides and skin inflammation in hairless mice.

Josai University
2015	Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin.

Kewpie Corporation
2015	Oral administration of hyaluronan prevents skin dryness and epidermal thickening in ultraviolet irradiated hairless mice.

Kwansei Gakuin University
2015	Extracellularly Extruded Syntaxin-4 Is a Potent Cornification Regulator of Epidermal Keratinocytes.

Kyungpook National University School of Medicine
2015	HR-1 Mice: A New Inflammatory Acne Mouse Model.

Tokyo University of Agriculture
2014	Ultraviolet B Irradiation Reduces the Expression of Adiponectin in Ovarial Adipose Tissues through Endocrine Actions of Calcitonin Gene-Related Peptide-Induced Serum Amyloid A.

Astellas Pharma Inc.
2013	Pharmacokinetics and pharmacodynamics of ASP2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection.

National Institute of Biomedical Innovation
2013	Zygosity Determination in Hairless Mice by PCR Based on Hr(hr) Gene Analysis.

South Dakota State University
2013	Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.

Global Technology Resource Center
2013	Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water.

Chung-Ang University
2013	Safety evaluation of stamp type digital microneedle devices in hairless mice.

Hamamatsu University School of Medicine
2013	Oral Intake of Beet Extract Provides Protection Against Skin Barrier Impairment in Hairless Mice.

Sungkyunkwan University School of Medicine
2012	The systemic effect of 830-nm LED phototherapy on the wound healing of burn injuries: A controlled study in mouse and rat models.

Fukushima Medical University
2011	Stratum corneum lipid structure investigated by EPR spin-probe method: application of terpenes.

Ajinomoto Co., Inc.
2011	Importance of amino acid composition to improve skin collagen protein synthesis rates in UV-irradiated mice.

Calpis Co., Ltd.
2010	Oral intake of Lactobacillus helveticus-fermented milk whey decreased transepidermal water loss and prevented the onset of sodium dodecylsulfate-induced dermatitis in mice.

Kinjirushi Co., Ltd.
2009	The effect of wasabi rhizome extract on atopic dermatitis-like symptoms in HR-1 hairless mice.

Snow Brand Milk Products Co., Ltd.
2008	Dietary phospholipid concentrate from bovine milk improves epidermal function in hairless mice.

Showa University
2008	Effects of oral administration of ciclosporin A on skin carcinogenesis: a study using the two-stage carcinogenesis protocol in mice.

Hatano Research Institute, Food and Drug Safety Center
2007	In vivo photochemical skin micronucleus test using a sunlight simulator: detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice.

Hokkaido University
2006	Dietary glucosylceramide improves skin barrier function in hairless mice.

Okayama University
2006	Characteristics of scratching behavior induced by some chemical mediators in hairless mice.

The Catholic University of Korea
2006	Altered immune cell proportions in the radiodermatitis induced hairless mice-1 (HR-1).

New drug deveropment research center, inc
2006	Usefulness of Hos:HR-1 mouse in antihistamine experiment.

Fujita Health University
2004	Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc.

Howard University
2004	Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models.

Osaka Medical College
2003	Measurement of retinoids and beta-carotene 15,15'-dioxygenase activity in HR-1 hairless mouse skin with UV exposure.

Hiroshima University
2003	Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse.

Gunma University
1995	Disaccharide analysis of the skin glycosaminoglycans in chronically ultraviolet light-irradiated hairless mice.