▶ Proper name

Hos:HRM-2

▶ Description

Homozygous mutants (Hr^hr/Hr^hr) show normal development of the first hair coat (first hair cycle). Starting at 2 weeks of age, they lose their hair coat rapidly and completely due to an abnormal second hair cycle [1, 2]. At weaning (~3 weeks of age), they are completely hairless [3].

▶ Appearance

pigmented, without hair, unaffected

▶ Genotype

Hr^hr/Hr^hr

▶ Reseach

ultraviolet radiation induced melanogenesis

▶ Development

We crossed a HR-1 male to a C3H female. A male mouse and two female mice were born in 2007. We named these mice Hos:HRM-2.

▶ Attention

Breeding is prohibited.

▶ References

[1] Brooke, H.C. 1926. Hairless mice. J. Hered. 17, 173–174.
[2] Sundberg, J. P. & King, L. E. Morphology of hair in normal and mutant laboratory mice. Eur. J. Dermatol. 11, 357–61
[3] Suzuki, O., Koura, M., Noguchi, Y., Uchio-Yamada, K. & Matsuda, J. Zygosity determination in hairless mice by PCR based on Hr(hr) gene analysis. Exp. Anim. 62, 267–73 (2013).