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Mice HR−1
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SHR/Hos     Spontaneously hypertensive rats
HR1

  Proper name SHR/Hos  
  Description  Spontaneously hypertensive rat (SHR) is an animal model of hypertension, used to study cardiovascular disease. It is the most studied model of hypertension measured as number of publications. [1]  
  Reseach hypertension and cardiovascular disease  
  Development  The SHR strain was obtained by Okamoto and colleagues in 1963, who started breeding Wistar-Kyoto rats with high blood pressure. [2] To Hoshino Laboratory Animals, Inc. from Jichi Medical University in 1972.  
  Attention The breeding is prohibited.  
  References [1] Pinto, Y. M., Paul, M. & Ganten, D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovasc. Res. 39, 77–88 (1998).

[2] OKAMOTO, K. & AOKI, K. Development of a strain of spontaneously hypertensive rats. Jpn. Circ. J. 27, 282–93 (1963).
 
  Indirect blood pressure measurement(January 20, 2009)
Materials:Softron BP-98A
Animals:SHR/Hos (10 week old, n=10)

【First】 Heart rate (HR) Systolic blood pressure (SBP) Mean blood pressure (MBP) Diastolic blood pressure (DBP)
First measurement 385 185 152 135
Second measurement 395 189 160 146
Third measurement 388 187 157 142
Average 389.3 187 156.3 141
Standard deviation (SD) 5.1 2.0 4.0 5.6
Standard error (SE) 3.0 1.2 2.3 3.2
Coefficient of variation (CV) 1.3 1.1 2.6 3.9

【Second】 HR SBP MBP DBP
First measurement 397 182 150 134
Second measurement 383 186 143 122
Third measurement 390 193 153 133
Average 390 187 148.7 129.7
Standard deviation (SD) 7.0 5.6 5.1 6.7
Standard error (SE) 4.0 3.2 3.0 3.8
Coefficient of variation (CV) 1.8 3.0 3.5 5.1

【Third】 HR SBP MBP DBP
First measurement 417 159 131 116
Second measurement 406 143 120 109
Third measurement 419 158 134 122
Average 414 153.3 128.3 115.7
Standard deviation (SD) 7.0 9.0 7.4 6.5
Standard error (SE) 4.0 5.2 4.3 3.8
Coefficient of variation (CV) 1.7 5.8 5.7 5.6

【Fourth】 HR SBP MBP DBP
First measurement 381 185 151 134
Second measurement 396 177 144 127
Third measurement 391 160 123 105
Average 389.3 174.0 139.3 122.0
Standard deviation (SD) 7.6 12.8 14.6 15.1
Standard error (SE) 4.4 7.4 8.4 8.7
Coefficient of variation (CV) 2.0 7.3 10.5 12.4

【Fifth】 HR SBP MBP DBP
First measurement 405 187 130 102
Second measurement 386 165 130 113
Third measurement 379 160 123 105
Average 390.0 170.7 127.7 106.7
Standard deviation (SD) 13.5 14.4 4.0 5.7
Standard error (SE) 7.8 8.3 2.3 3.3
Coefficient of variation (CV) 3.4 8.4 3.2 5.3

【Sixth】 HR SBP MBP DBP
First measurement 379 166 126 106
Second measurement 382 172 134 114
Third measurement 370 149 115 98
Average 377.0 162.3 125.0 106.0
Standard deviation (SD) 6.2 11.9 9.5 8.0
Standard error (SE) 3.6 6.9 5.5 4.6
Coefficient of variation (CV) 1.7 7.3 7.6 7.5

【Seventh】 HR SBP MBP DBP
First measurement 364 186 142 120
Second measurement 393 188 155 139
Third measurement 375 171 121 96
Average 377.3 181.7 139.3 118.3
Standard deviation (SD) 14.6 9.3 17.2 21.5
Standard error (SE) 8.5 5.4 9.9 12.4
Coefficient of variation (CV) 3.9 5.1 12.3 18.2

【Eighth】 HR SBP MBP DBP
First measurement 411 187 163 151
Second measurement 364 199 151 127
Third measurement 378 175 122 96
Average 384.3 187.0 145.3 124.7
Standard deviation (SD) 24.1 12.0 21.1 27.6
Standard error (SE) 13.9 6.9 12.2 15.9
Coefficient of variation (CV) 6.3 6.4 14.5 22.1

【Ninth】 HR SBP MBP DBP
First measurement 419 184 161 150
Second measurement 399 181 147 130
Third measurement 400 175 144 128
Average 406.0 180.0 150.7 136.0
Standard deviation (SD) 11.3 4.6 9.1 12.2
Standard error (SE) 6.5 2.6 5.2 7.0
Coefficient of variation (CV) 2.8 2.5 6.0 8.9

【Tenth】 HR SBP MBP DBP
First measurement 396 172 139 123
Second measurement 431 169 143 130
Third measurement 400 168 139 125
Average 409.0 169.7 140.3 126.0
Standard deviation (SD) 19.2 2.1 2.3 3.6
Standard error (SE) 11.1 1.2 1.3 2.1
Coefficient of variation (CV) 4.7 1.2 1.6 2.9
 

References         Order