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Proper name |
SHR/Hos |
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Description |
Spontaneously hypertensive rat (SHR) is an animal model of hypertension, used to study cardiovascular disease. It is the most studied model of hypertension measured as number of publications. [1] |
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Reseach |
hypertension and cardiovascular disease, attention- deficit hyperactivity disorder (ADHD) [2] |
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Development |
The SHR strain was obtained by Okamoto and colleagues in 1963, who started breeding Wistar-Kyoto rats with high blood pressure. [3] To Hoshino Laboratory Animals, Inc. from Jichi Medical University in 1972. |
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Attention |
The breeding is prohibited. |
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References |
[1] Pinto, Y. M., Paul, M. & Ganten, D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovasc. Res. 39, 77–88 (1998).
[2] NISHIGAKI, R. & YOKOYAMA, Y. Monosodium glutamate ingestion during the development period reduces aggression mediated by the vagus nerve in a rat model of attention deficit-hyperactivity disorder. Brain Research 1690 (2018) 40–50.
[3] OKAMOTO, K. & AOKI, K. Development of a strain of spontaneously hypertensive rats. Jpn. Circ. J. 27, 282–93 (1963). |
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Materials：Softron BP-98A
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Indirect blood pressure measurement（January 20, 2009）
Materials：Softron BP-98A
Animals：SHR/Hos (10 week old, n=10)
| 【First】 |
Heart rate (HR) |
Systolic blood pressure (SBP) |
Mean blood pressure (MBP) |
Diastolic blood pressure (DBP) |
| First measurement |
385 |
185 |
152 |
135 |
| Second measurement |
395 |
189 |
160 |
146 |
| Third measurement |
388 |
187 |
157 |
142 |
| Average |
389.3 |
187 |
156.3 |
141 |
| Standard deviation (SD) |
5.1 |
2.0 |
4.0 |
5.6 |
| Standard error (SE) |
3.0 |
1.2 |
2.3 |
3.2 |
| Coefficient of variation (CV) |
1.3 |
1.1 |
2.6 |
3.9 |
| 【Second】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
397 |
182 |
150 |
134 |
| Second measurement |
383 |
186 |
143 |
122 |
| Third measurement |
390 |
193 |
153 |
133 |
| Average |
390 |
187 |
148.7 |
129.7 |
| Standard deviation (SD) |
7.0 |
5.6 |
5.1 |
6.7 |
| Standard error (SE) |
4.0 |
3.2 |
3.0 |
3.8 |
| Coefficient of variation (CV) |
1.8 |
3.0 |
3.5 |
5.1 |
| 【Third】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
417 |
159 |
131 |
116 |
| Second measurement |
406 |
143 |
120 |
109 |
| Third measurement |
419 |
158 |
134 |
122 |
| Average |
414 |
153.3 |
128.3 |
115.7 |
| Standard deviation (SD) |
7.0 |
9.0 |
7.4 |
6.5 |
| Standard error (SE) |
4.0 |
5.2 |
4.3 |
3.8 |
| Coefficient of variation (CV) |
1.7 |
5.8 |
5.7 |
5.6 |
| 【Fourth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
381 |
185 |
151 |
134 |
| Second measurement |
396 |
177 |
144 |
127 |
| Third measurement |
391 |
160 |
123 |
105 |
| Average |
389.3 |
174.0 |
139.3 |
122.0 |
| Standard deviation (SD) |
7.6 |
12.8 |
14.6 |
15.1 |
| Standard error (SE) |
4.4 |
7.4 |
8.4 |
8.7 |
| Coefficient of variation (CV) |
2.0 |
7.3 |
10.5 |
12.4 |
| 【Fifth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
405 |
187 |
130 |
102 |
| Second measurement |
386 |
165 |
130 |
113 |
| Third measurement |
379 |
160 |
123 |
105 |
| Average |
390.0 |
170.7 |
127.7 |
106.7 |
| Standard deviation (SD) |
13.5 |
14.4 |
4.0 |
5.7 |
| Standard error (SE) |
7.8 |
8.3 |
2.3 |
3.3 |
| Coefficient of variation (CV) |
3.4 |
8.4 |
3.2 |
5.3 |
| 【Sixth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
379 |
166 |
126 |
106 |
| Second measurement |
382 |
172 |
134 |
114 |
| Third measurement |
370 |
149 |
115 |
98 |
| Average |
377.0 |
162.3 |
125.0 |
106.0 |
| Standard deviation (SD) |
6.2 |
11.9 |
9.5 |
8.0 |
| Standard error (SE) |
3.6 |
6.9 |
5.5 |
4.6 |
| Coefficient of variation (CV) |
1.7 |
7.3 |
7.6 |
7.5 |
| 【Seventh】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
364 |
186 |
142 |
120 |
| Second measurement |
393 |
188 |
155 |
139 |
| Third measurement |
375 |
171 |
121 |
96 |
| Average |
377.3 |
181.7 |
139.3 |
118.3 |
| Standard deviation (SD) |
14.6 |
9.3 |
17.2 |
21.5 |
| Standard error (SE) |
8.5 |
5.4 |
9.9 |
12.4 |
| Coefficient of variation (CV) |
3.9 |
5.1 |
12.3 |
18.2 |
| 【Eighth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
411 |
187 |
163 |
151 |
| Second measurement |
364 |
199 |
151 |
127 |
| Third measurement |
378 |
175 |
122 |
96 |
| Average |
384.3 |
187.0 |
145.3 |
124.7 |
| Standard deviation (SD) |
24.1 |
12.0 |
21.1 |
27.6 |
| Standard error (SE) |
13.9 |
6.9 |
12.2 |
15.9 |
| Coefficient of variation (CV) |
6.3 |
6.4 |
14.5 |
22.1 |
| 【Ninth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
419 |
184 |
161 |
150 |
| Second measurement |
399 |
181 |
147 |
130 |
| Third measurement |
400 |
175 |
144 |
128 |
| Average |
406.0 |
180.0 |
150.7 |
136.0 |
| Standard deviation (SD) |
11.3 |
4.6 |
9.1 |
12.2 |
| Standard error (SE) |
6.5 |
2.6 |
5.2 |
7.0 |
| Coefficient of variation (CV) |
2.8 |
2.5 |
6.0 |
8.9 |
| 【Tenth】 |
HR |
SBP |
MBP |
DBP |
| First measurement |
396 |
172 |
139 |
123 |
| Second measurement |
431 |
169 |
143 |
130 |
| Third measurement |
400 |
168 |
139 |
125 |
| Average |
409.0 |
169.7 |
140.3 |
126.0 |
| Standard deviation (SD) |
19.2 |
2.1 |
2.3 |
3.6 |
| Standard error (SE) |
11.1 |
1.2 |
1.3 |
2.1 |
| Coefficient of variation (CV) |
4.7 |
1.2 |
1.6 |
2.9 |
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HR−１