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Mice HR−1
  HRM-2
  HR/DeF1
  NSY
Rats ZFDM
  OLETF
  LETO
  SHR
  SHRSP
  WKY
etc. HR-AD diet
HR-AD diet
 

Special diet inducing
mouse model of atopic dermatitis

 
 
HRAD
Left : HR-AD-fed mice  Right : Normal diet-fed mice

 
  Description  HR-1 hairless mice fed a commercial special diet, HR-AD, develop atopic dermatitis-like skin inflammation with prolonged spontaneous scratching, and that skin barrier dysfunction is involved in the basal scratching. [1]
 HR-AD-fed mice showed severe dry skin symptoms accompanied by a decrease in dermal water content and an increase in transepidermal water loss and prolonged scratching bout duration on day 14 or 28. These symptoms became gradually worse until day 56. [2]
 
  Reseach Atopic dermatitis  
  Development Skin dryness and wrinkle-like changes, scratching behaviour, decreased skin water content, increased transepidermal water loss and raised blood immunoglobulin E levels were seen in the group receiving the diet compared with control mice. [3] HR-AD diets were made as described in [3]. Deficiency of n-6 PUFAs is mainly responsible for AD-like symptoms by HR-AD feeding.[4]  
  References [1] Ethanol aggravates itch-related scratching in hairless mice developing atopic dermatitis.
[2] Atopic dermatitis-like pruritic skin inflammation caused by feeding a special diet to HR-1 hairless mice.
[3] Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc.
[4] Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice.
 

References         Order